November 2024

Fatty acid and Triglyceride synthesis- Case-based multiple-choice questions

Practice questions, USMLE styled question bank /

1. Which of the following TCA cycle intermediates plays a crucial role in de novo fatty acid synthesis by providing substrate and positively regulating the rate-limiting enzyme involved in fatty acid synthesis? A. Citrate B. Isocitrate C. Malate D. Oxaloacetate E. Succinate   Correct Answer: A. Citrate. Citrate plays a crucial role in de novo […]

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Glycogen Storage Diseases- Multiple Choice Questions

Practice questions, Quick Revision Series, USMLE styled question bank /

1. A 3-month-old male infant presents with poor feeding, hypotonia, and cardiomegaly on physical exam. Blood tests reveal elevated lactate, uric acid, and creatine kinase levels. Echocardiogram demonstrates hypertrophic cardiomyopathy. A muscle biopsy shows excessive glycogen storage in lysosomes. Which enzyme deficiency is most likely responsible for this infant’s condition? A. Glucose-6-phosphatase B. Debranching enzyme

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Glycogen storage diseases with mnemonics to aid memorization

Quick Revision Series /

A table summarizing the main glycogen storage diseases (GSDs) with enzyme defects, key clinical features, and mnemonics to aid memorization: Glycogen Storage Disease Enzyme Defect Key Clinical Features Mnemonic Type I: von Gierke Disease (GSD I) Glucose-6-phosphatase Severe fasting hypoglycemia, hepatomegaly, lactic acidosis, hyperlipidemia, hyperuricemia “von Gierke: ‘G6P’s Gone, Liver Left Low” Type II: Pompe

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Glycogen Metabolism- Multiple-Choice Questions with Complete explanations-Part-1

Practice questions, USMLE styled question bank /

1. Imagine you’re preparing for a long-distance marathon and need sustained energy throughout the race. Which of the following organs stores the maximum amount of glycogen that your body can use during prolonged exercise? A. Adipose tissue B. Cardiac muscle C. Kidney D. Liver E. Skeletal muscle   The correct answer is E. Skeletal muscle:

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Multiple-Choice Questions- HMP/Pentose phosphate pathway

Practice questions, USMLE styled question bank /

1. A researcher is investigating the effect of an enzyme whose reaction product is crucial for de novo fatty acid synthesis. Which of the following enzymes is most likely the focus of this study? A. Acyl CoA Dehydrogenase B. Glucose-6-Phosphatase C. Glucose-6-Phosphate Dehydrogenase (G-6PD) D. Lactate Dehydrogenase E. Phosphofructokinase-1 (PFK-1)   Correct Answer – C.

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