NBME-Style Case-Based Questions on the regulation of glycolysis with explanations

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Question 1: A 25-year-old man runs a marathon. After 20 miles, his muscle cells are relying heavily on glycolysis for energy production. Which of the following changes is most likely increasing the rate of glycolysis in his muscles? A. Accumulation of alanine B. Decreased availability of glucose C. Decreased oxygen levels D. Increased AMP concentration […]

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Summary of Regulation of Glycolysis

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Glycolysis is the metabolic pathway that converts glucose into pyruvate, generating ATP and NADH in the process. It occurs in the cytoplasm of cells and is essential for energy production. Glycolysis is regulated at multiple levels to match energy demand with supply. Modes of Glycolysis Regulation Substrate Concentration The availability of glucose directly influences the

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Amino Acid Metabolism- Set 2- Multiple Choice Questions

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Q.1 – A 12-year-old boy develops convulsions. After an Electroencephalogram (EEG), a neurologist determines that the child has epilepsy. He is started on benzodiazepine, which promotes the activity of GABA. GABA is derived from Glutamate by which of the following reactions? A) Deamination B) Decarboxylation C) Dehydrogenation D) Hydroxylation E) Transamination Answer: B) Decarboxylation Explanation:

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Amino acid Metabolism- Multiple-Choice Questions- Set 1

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Q.1 – Which of the following is a common compound shared by the TCA and Urea cycles? A) α-Ketoglutarate B) Succinyl-CoA C) Oxaloacetate D) Fumarate Answer: D) Fumarate Explanation: Fumarate is a common compound in both the TCA (Tricarboxylic Acid) and urea cycles. In the TCA cycle, fumarate is formed from succinate by the enzyme

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Enzymology Revision (Multiple Choice Questions With Complete Explanations)

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Q.1: Glycogen phosphorylase, which mobilizes glycogen for energy, requires which of the following as a cofactor? Adenosyl Cobalamine Coenzyme A Pyridoxal phosphate Tetrahydrofolate Thiamine pyrophosphate Correct Answer: C) Pyridoxal phosphate Explanation: Glycogen phosphorylase is instrumental in the process of glycogenolysis, where it facilitates the breakdown of glycogen into glucose-1-phosphate, thereby playing a vital role in

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