Hexokinase vs Glucokinase Regulation Feature Hexokinase Glucokinase Mnemonic Location Most tissues (muscle, brain) Liver and pancreatic β-cells “H in Human Tissues, G in Glucose Factories” Affinity for Glucose (Km) Low Km (high affinity) High Km (active only at high glucose) “Hexokinase is Hungry, Glucokinase is Greedy” Allosteric Inhibition Inhibited by Glucose-6-Phosphate No inhibition by Glucose-6-Phosphate […]

Type of Inhibition Effect on Vmax and Km Reversible / Irreversible Examples Mnemonic Competitive (Inhibitor competes with substrate for the active site) Vmax: Unchanged Km: Increased Reversible 1) Statins – inhibit HMG-CoA Reductase (cholesterol-lowering) 2) PABA – inhibits Pteroyl Synthase (antibiotic) 3) Captopril – inhibits ACE (antihypertensive) 4) Oxamate – inhibits Lactate Dehydrogenase (poison) 5)

Here’s a table showing the amino acids associated with each intermediate and helpful mnemonics to aid memorization: Intermediate Amino Acids Associated Mnemonic for Amino Acid Entry Points Pyruvate Glycine, Alanine, Serine, Cysteine, Threonine, Tryptophan, Hydroxyproline G – Glycine A – Alanine S – Serine C – Cysteine T – Threonine T – Tryptophan H – Hydroxyproline

Glycolysis is the metabolic pathway that converts glucose into pyruvate, generating ATP and NADH in the process. It occurs in the cytoplasm of cells and is essential for energy production. Glycolysis is regulated at multiple levels to match energy demand with supply. Modes of Glycolysis Regulation Substrate Concentration The availability of glucose directly influences the