PDH complex and the TCA cycle- NBME style questions set-2

Practice questions, USMLE styled question bank /

1. The cytosolic isoform of which of the following TCA cycle enzymes requires NADP⁺ as a coenzyme, which can be utilized in the reduced state for reductive biosynthesis? A. Aconitase B. Citrate Synthase C. Isocitrate Dehydrogenase D. Malate Dehydrogenase E. Succinate Dehydrogenase The correct answer is C: Isocitrate Dehydrogenase: The cytosolic isoform of isocitrate dehydrogenase […]

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PDH complex and the TCA cycle- NBME style questions set-1

Practice questions, USMLE styled question bank /

1. A 24-year-old woman presents with diarrhea, dysphagia, jaundice, and white transverse lines on her fingernails (Mee’s lines). She is diagnosed with arsenic poisoning. Arsenic poisoning inhibits which of the following enzymes? A. Citrate synthase B. Isocitrate dehydrogenase C. Malate dehydrogenase D. Succinate dehydrogenase E. α-Keto glutarate dehydrogenase complex Correct answer: E. α-Keto glutarate dehydrogenase

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Glycolysis Review- NBME style questions with complete explanations

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Q.1 Identify the Phosphoester that is predominantly encountered in erythrocytes and plays a vital role in modulating the oxygen-binding affinity of hemoglobin: A. 1,3-Bisphosphoglycerate B. 2,3-Bisphosphoglycerate C. Fructose 1,6-bisphosphate D. Fructose 6-phosphate E. Glucose 6-phosphate The correct answer is B. 2,3-Bisphosphoglycerate (2,3-BPG): 2,3-Bisphosphoglycerate is a negatively charged molecule found in high concentrations within erythrocytes. 2,3-BPG

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NBME-Style Case-Based Questions on the regulation of glycolysis with explanations

Quick Revision Series, USMLE styled question bank /

Question 1: A 25-year-old man runs a marathon. After 20 miles, his muscle cells are relying heavily on glycolysis for energy production. Which of the following changes is most likely increasing the rate of glycolysis in his muscles? A. Accumulation of alanine B. Decreased availability of glucose C. Decreased oxygen levels D. Increased AMP concentration

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Summary of Regulation of Glycolysis

Quick Revision Series /

Glycolysis is the metabolic pathway that converts glucose into pyruvate, generating ATP and NADH in the process. It occurs in the cytoplasm of cells and is essential for energy production. Glycolysis is regulated at multiple levels to match energy demand with supply. Modes of Glycolysis Regulation Substrate Concentration The availability of glucose directly influences the

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Amino Acid Metabolism- Set 2- Multiple Choice Questions

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Q.1 – A 12-year-old boy develops convulsions. After an Electroencephalogram (EEG), a neurologist determines that the child has epilepsy. He is started on benzodiazepine, which promotes the activity of GABA. GABA is derived from Glutamate by which of the following reactions? A) Deamination B) Decarboxylation C) Dehydrogenation D) Hydroxylation E) Transamination Answer: B) Decarboxylation Explanation:

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Amino acid Metabolism- Multiple-Choice Questions- Set 1

Practice questions, USMLE styled question bank /

Q.1 – Which of the following is a common compound shared by the TCA and Urea cycles? A) α-Ketoglutarate B) Succinyl-CoA C) Oxaloacetate D) Fumarate Answer: D) Fumarate Explanation: Fumarate is a common compound in both the TCA (Tricarboxylic Acid) and urea cycles. In the TCA cycle, fumarate is formed from succinate by the enzyme

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