Biotin- Chemistry, Functions and Clinical Significance
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pyruvate carboxylase
Transportation of Acetyl CoA
Fatty acids are synthesized in the cytosol, whereas acetyl CoA is formed from pyruvate in mitochondria. Hence, acetyl CoA must be transferred from mitochondria to the cytosol. Mitochondria, however, are not readily permeable to acetyl CoA. Carnitine carries only long-chain fatty acids. The barrier to acetyl CoA is bypassed by citrate, which carries acetyl groups
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Summary- Regulation of Major Pathways Of Carbohydrate metabolism
Enzyme Pathway Effect of Substrate Concentration Allosteric Modification/ Feedback Inhibition Induction/Repression Clinical Significance Hexokinase Glycolysis Feedback inhibition by Glucose-6-P – Deficiency causes Hemolytic anemia. Glucokinase Glycolysis Stimulated by a high carbohydrate diet Activity decreases during fasting – Induced by Insulin Repressed by Glucagon Activity low in Diabetes Mellitus Phosphofructokinase-1 Glycolysis Stimulated by a high
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Hypoglycemia Due To Biotin deficiency
A 32-year-old bodybuilder has decided to go on a diet consisting of egg whites to ensure only proteins for muscle growth. After a few weeks, he experiences decreased energy and is found to be hypoglycemic. A nutritionist tells the patient that he most likely has a deficiency of vitamin Biotin. Which of the following enzymes
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