Biosynthesis of cholesterol- a quick revision

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Biosynthesis of cholesterol The biosynthesis of cholesterol may be divided into five steps: (1) Synthesis of Mevalonate from acetyl-CoA. (2) Formation of Isoprenoid units from Mevalonate by loss of CO2. (3) Condensation of six isoprenoid units forms Squalene. (4) The cyclization of Squalene gives rise to the parent steroid, Lanosterol. (5)Formation of cholesterol from lanosterol.

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The reaction catalyzed by HMG Co-A Reductase

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Case Details A 40-year-old man presents with chest pain that radiates to his left jaw and shoulder. He is diagnosed with a myocardial infarct (heart attack) and is prescribed statin medication. Statins are competitive inhibitors of HMG CoA reductase, which converts HMG Co A to which of the following? Isopentenyl pyrophosphate Mevalonate Geranyl pyrophosphate Farnesyl

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