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Biosynthesis of cholesterol- a quick revision

Energy metabolism, Learning resources, Library, Metabolism of lipids, PowerPoint Presentations, PowerPoint presentations, Presentations, Quick Revision Series, Quick revisions, USMLE Content /

Biosynthesis of cholesterol The biosynthesis of cholesterol may be divided into five steps: (1) Synthesis of Mevalonate from acetyl-CoA. (2) Formation of Isoprenoid units from Mevalonate by loss of CO2. (3) Condensation of six isoprenoid units forms Squalene. (4) The cyclization of Squalene gives rise to the parent steroid, Lanosterol. (5)Formation of cholesterol from lanosterol.

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Starvation induced metabolic alterations

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 A 23 –year- old female was brought for consultation by her mother, who was troubled by her daughter’s continuous fatigue, dizziness, and loss of weight. The patient was 6 feet 2 inches tall and weighed 100 pounds. Further questioning revealed that the young woman had been virtually fasting for four months, hoping to obtain a

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Question of the week

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Case details A 54- year-old man with Type 1 diabetes is referred to an ophthalmologist for evaluation of developing cataracts. Blood chemistry results are shown below: Fasting blood glucose   198 mg/dl Hemoglobin A                  15 gm/dl Hemoglobin A1c             10% of total Hb Urine ketones                   Positive Urine glucose                    Positive Which of the following enzymes is most strongly

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