A 23 –year- old female was brought for consultation by her mother, who was troubled by her daughter’s continuous fatigue, dizziness, and loss of weight. The patient was 6 feet 2 inches tall and weighed 100 pounds. Further questioning revealed that the young woman had been virtually fasting for four months, hoping to obtain a […]
Starvation induced metabolic alterations Read More »
Q.- Adenosine triphosphate (ATP) is the energy currency within the cell. Which of the following best describes the type of compound ATP is? A. Phospholipid B. Amino acid C. Nucleotide D. Triacylglycerol E. Oligosaccharide. Details The correct answer is -C- Nucleotide. The nucleotide coenzyme adenosine triphosphate (ATP) is the most important form of chemical energy
ATP- The energy currency within the cell Read More »
Case details A 5- year-old boy suffered gastroenteritis for two days and was brought to the emergency in the semiconscious state. Blood glucose at the time of admission was 45 mg/dl and his urine was negative for glucose and ketone bodies. Glucose was administered intravenously and his condition improved within 10 minutes. Subsequent laboratory investigations
Elevated Acyl carnitine compounds and associated hypoglycemia- What is the defect? Read More »
A postoperative patient on intravenous fluids develops lesions in the mouth (angular stomatitis). Urinalysis indicates an excretion of 15 μg riboflavin/mg creatinine, which is abnormally low. Which of the following TCA cycle enzymes is most likely to be affected? Citrate synthase Isocitrate dehydrogenase Fumarase Malate dehydrogenase Succinate dehydrogenase Details- E) – Succinate dehydrogenase is the
Impaired TCA cycle enzyme activity in angular stomatitis Read More »
A 32-year-old bodybuilder has decided to go on a diet consisting of egg whites to ensure only proteins for muscle growth. After a few weeks, he experiences decreased energy and is found to be hypoglycemic. A nutritionist tells the patient that he most likely has a deficiency of vitamin Biotin. Which of the following enzymes
Hypoglycemia due to Biotin deficiency Read More »
A 22-year-old man collapsed from dehydration during maneuvers in the desert and was sent to an emergency. A high level of glucose was observed in his urine. He was suspected of being a diabetic. Further tests, however, determined that his serum insulin level was normal. A glucose tolerance test exhibited a normal pattern; further testing
Clinical significance of SGLT-2 Read More »
Case details A 15- year-old boy had numbness and tingling around his mouth and in his fingertips. The problem was intermittent usually occurring during times of great stress. Aside from his problem, he had been in good health. His physical examination was normal, as were his laboratory values, especially his total calcium concentration was 2.5
Stress-induced hypocalcemia Read More »
Case details-1 A 45 year-old-female suffering from bronchial asthma was brought to an emergency in a critical state with extreme difficulty in breathing. The blood gas analysis revealed the following pH- 7.3 PCO2- 46 mm Hg PO2- 55 mm Hg HCO3- 24meq/L What is your Interpretation? Case discussion- Low pH – acidosis Low PO2
Case studies- Acid Base Balance and Imbalance Read More »
Case details A 6-year-old boy is seen by a pediatrician because his parents are concerned about his aggressive behavior, hyperactivity, and a loss of language skills. He also has recently become increasingly unsteady on his feet and has experienced a recent seizure. Slight facial feature coarsening is noted. In which of the following processes is this child
Sanfilippo syndrome Read More »
A 57 -year-old man has been admitted with congestive heart failure. He has been given Digoxin, which helps the heart to beat more strongly and regularly. Digoxin is an ester that contains a sugar component (glycol) and a nonsugar (aglycone) component attached via oxygen. Digoxin should be best classified as a: A. Disaccharide B. Glycoprotein
Digoxin- Chemistry and mechanism of action Read More »
