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Practice questions-set-2
Q.1- A 50- year-old male is seen in the emergency with a severe headache. His blood pressure is 210/130 mm Hg. Evidence of retinal hemorrhage and epistaxis is also there. He has been given an infusion of nitroprusside. Which of the following processes is directly affected by the active metabolite of this drug?
a) Phospholipase A2
b) Phospholipase C
c) Guanylate cyclase
d) Phosphodiesterase
Q.2- Phenylketonuria is characterized by which of the following?
a) Urine turning black on standing
b) The wolf-like smell of urine
c) The mousy odor of urine
d) The smell of burnt sugar in urine
Q.3- The active form of Methionine is-
a) S- Acetyl methionine
b) S- Carboxyl methionine
c) S- Adenosyl methionine
d) N-acetyl methionine
Q.4- Patients with inherited defects of mitochondria involving components of the respiratory chain and oxidative phosphorylation present with all except-
a) Myopathy
b) Lactic acidosis
c) Encephalopathy
d) Mental retardation
Q.5- Which of the following best describes the toxicity associated with Atractyloside
a) Acts as an inhibitor of ETC
b) Acts as an uncoupler
c) Acts as an inhibitor of ATP/ADP transporter
d) Inactivates ATP synthase complex
Q.6- A given substrate may be acted on by a number of different enzymes, each of which uses the same substrate(s) and produces the same product(s). The individual members of a set of enzymes sharing such characteristics are known as-
a) Group-specific enzymes
b) Isoenzymes
c) Substrate specific enzymes
d) Allosteric enzymes
Q.7- Porphyrins are deposited in teeth and in bones. As a result, the teeth are reddish-brown and fluoresce on exposure to long-wave ultraviolet light, so-called ‘Erythrodontia, ‘which is a sign of which porphyria?
a) Variegate porphyria
b) Acute intermittent porphyria
c) Congenital Erythropoietic porphyria
d) Hereditary Coproporphyria
Q.8- Which of the following reactions generates ATP-
a) Glucose to Glucose -6-phosphate
b) Pyruvate to Lactate
c) Phosphoenol pyruvate to Pyruvate
d) Glucose- 6-P to fructose-6 -P
Q.9- Formation of Galactose-1-P from Galactose is catalyzed by-
a) Hexokinase
b) Aldolase
c) Galactokinase
d) Galactose-1-P Uridyl transferase
Q.10- Which of the following is a cofactor in the reaction catalyzed by glyceraldehyde 3-phosphate dehydrogenase?
a) ATP
b) Cu2+
c) Heme
d) NAD+
Q.11- Which of the following enzymes is not TPP-dependent?
a) PDH Complex
b) α- Keto glutarate dehydrogenase complex
c) Tryptophan pyrrolase
d) Transaminase
Q.12- Which of the following amino acids carries a net positive charge at the physiological pH?
a) Valine
b) Leucine
c) Isoleucine
d) None of the above.
Q.13- All of the following except one are coupling agents for the detoxification of xenobiotics-
a) Glutamic acid
b) Cysteine
c) Methionine
d) Glycine
Q.14- Which of the following is produced due to detoxification by Glycine?
a) Mercapturic acid
b) Hippuric acid
c) Kynurenine acid
d) Xanthurenic acid
Q.15- Which of the following is a non-reducing sugar?
a) Arabinose
b) Trehalose
c) Erythrose
d) Ribulose
Q.16- Which of the following is not an uncoupler of oxidative phosphorylation?
a) Atractyloside
b) Dicumarol
c) Thyroxin
d) Calcium
Q.17- Which of the following is not a product of tyrosine metabolism?
a) Melanin
b) Melatonin
c) Thyroxin
d) Tyramine
Q.18- Spot the inborn error whose early diagnosis is essential to avoid permanent brain damage.
a) Phenylketonuria
b) Glycogen storage disease
c) Thalassemia
d) Acute Intermittent Porphyria
Q.19- Downregulation of LDL receptor occurs due to which of the following?
a) Influx of cholesterol
b) Decreased activity of LCAT
c) Steroid synthesis
d) Bile acid synthesis
Q.20- Which of the following hormones promotes hypoglycemia?
a) Epinephrine
c) Norepinephrine
b) Glucagon
d) Insulin
Key To Answers-
1)- c, 2)-c, 3)-c, 4)- d, 5)- c, 6)- b, 7)- c, 8)-c, 9)-d, 10)-d,11)-d,12)-d,13)-a, 14)-b,15)-b,16)-a,17)-b,18)-a, 19)-a,20)-d.
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