Protein chemistry- Multiple-choice questions- set-2

1) – A mutation has changed an isoleucine residue of a protein to glutamic acid; which statement best describes its location in a hydrophilic exterior?

a) On the surface, since it is hydrophilic

b) Inside the core of the protein since it is hydrophobic

c) Anywhere inside or outside

d) Inside the core of protein since it has a polar but uncharged side chain

2) – Glycine and proline are the most abundant amino acids in the structure of- which of the following?

a) Hemoglobin

b) Myoglobin

c) Insulin

d) Collagen

3) – Some proteins contain additional amino acids that arise by modification of an amino acid already present in a peptide; examples include which of the following?

a) 4 -hydroxyproline

b) 5- hydroxylysine

c) Gamma Amino Butyric Acid

d) All of the above.

4) – Choose the incorrect statement out of the following:

a) Only L amino acids are found in the biological system

b) Glycine is optical inactive

c) Tyrosine is a modified amino acid

d) Seleno cysteine is the 21st amino acid

5) – Choose a nano peptide out of the following-

a) Oxytocin

b) Vasopressin

c) Bradykinin

d) All of the above.

6) – Which of the following amino acids carries a net positive charge at the physiological pH ?

a) Valine

b) Leucine

c) Isoleucine

d) None of the above 

7) – Which of the following amino acids is a precursor for a mediator of allergies and inflammation?

a) Histidine

b) Tyrosine

c) Phenylalanine

d) Tryptophan

8) – The mother of a malnourished child has been instructed to include a complete protein in the diet for her child; which of the following proteins should be recommended?

a) Pulses

b) Wheat

c) Soy Protein

d) Milk

9) – All of the below-mentioned amino acids can participate in hydrogen bonding except one –

a) Serine

b) Cysteine

c) Threonine

d) Valine

10) – All of the following amino acids are both glucogenic as well as ketogenic except:

a) Isoleucine

b) Leucine

c) Tyrosine

d) Phenylalanine

11) – Which of the following amino acids is a precursor of niacin (Vitamin)?

a) Tyrosine

b) Threonine

c) Tryptophan

d) Phenylalanine

12) – The greatest buffering capacity at physiological pH would be provided by a protein-rich in which of the following amino acids?

a) Serine

b) Cysteine

c) Alanine

d) Histidine

13) – Which of the following peptides is cyclic-?

a) Glutathione

b) Gramicidin

c) Met encephalin

d) Leuencephalin

14) – Which of the following is not a fibrous protein?

a) Carbonic anhydrase

b) Collagen

c) Fibrinogen

d) Keratin

15)-Which of the following amino acids is a limiting amino acid in pulses?

a) Leucine

b) Lysine

c) Methionine

d) Glutamine

16)- Which of the following is not a hemoprotein?

a) Catalase

b) Myeloperoxidase

c) Glutathione peroxidase

d) Aconitase

17) – All the below-mentioned proteins are metalloproteins except-

a) Carbonic anhydrase

b) Xanthine oxidase

c) Lactate dehydrogenase

d) Superoxide dismutase                                                                                                       

18) – Which of the following is a peptide antibiotic?

a) Erythromycin

b) Gramicidin

c) Ciprofloxacin

d) Tetracycline

19) – Choose the Anticancer peptide out of the following-

a) Bleomycin

b) Methotrexate

c) Cytosine Arabinoside

d) Dideoxyinosine

20) – Which of the following amino acids is most compatible with an α-helical structure?

a) Tryptophan

b) Alanine

c) Leucine

d) Proline

21) – Which of the following can be found with the highest concentration of cystine?

a) Melanin

b) Keratin

c) Collagen

d) Myosin

22) – In scurvy, which amino acid that is usually part of collagen is not synthesized?

a) Hydroxy-tryptophan

b) Hydroxy-tyrosine

c) Hydroxy-alanine

d) Hydroxy-proline

23) – A child with tall stature, loose joints, and detached retinas is found to have a mutation in collagen. Which of the following amino acids is the recurring amino acid most likely to be altered in mutations that distort collagen molecules?

a) Glycine

b) Tyrosine

c) Tryptophan

d) Tyrosine

24) – Which one of the following amino acids may be considered a hydrophobic amino acid at physiological p H of 7.4?

a) Isoleucine

b) Arginine

c) Aspartic acid

d) Threonine

25) – Which of the characteristics below apply to the amino acid Glycine?

a) Optically inactive

b) Hydrophilic, basic, and charged

c) Hydrophobic

d) Hydrophilic, acidic, and charged

26) – Which of the following amino acids in myoglobin, a globular protein, is highly likely to be localized within the interior of the molecule?

a) Arginine

b) Valine

c) Aspartic acid

d) Lysine

 27) – Which of the amino acids below is the uncharged derivative of an acidic amino acid?

a) Cystine

b) Tyrosine

c) Glutamine

d) Serine

28) – Choose the correct category for milk protein casein out of the following-

a) Nucleoprotein

b) Phosphoprotein

c) Lipoprotein

d)  Glycoprotein

Answers-

1-      a

2-      d

3-      d

4-      c

5-      d

6-      d

7-      a

8-      d

9-      d

10-   b

11-   c

12-   d

13-   b

14-   a

15-   c

16-   d

17-   c

18-   b

19-   a

20-   b

21-   b

22-   d

23-   a

24-   a

25-   a

26-   b

27-   c

28-   b

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