Alzheimer disease
Protein Structure, Unfolding, and Misfolding
Denaturation involves protein unfolding, i.e., disruption of higher orders of protein structure, secondary, tertiary and quaternary structure (if present), the primary structure remains intact.
Protein misfolding diseases
Alzheimer's disease is characterized by loss of neurons and synapses in the cerebral cortex and certain subcortical regions. This loss results in gross atrophy of the affected regions, including degeneration in the temporal lobe and parietal lobe, and parts of the frontal cortex and cingulate gyrus.