USMLE styled question bank

PDH complex and the TCA cycle- NBME style questions set-1

1. A 24-year-old woman presents with diarrhea, dysphagia, jaundice, and white transverse lines on her fingernails (Mee’s lines). She is diagnosed with arsenic poisoning. Arsenic poisoning inhibits which of the following enzymes? A. Citrate synthase B. Isocitrate dehydrogenase C. Malate dehydrogenase D. Succinate dehydrogenase E. α-Keto glutarate dehydrogenase complex Correct answer: E. α-Keto glutarate dehydrogenase […]

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Glycolysis Review- NBME style questions with complete explanations

Q.1 Identify the Phosphoester that is predominantly encountered in erythrocytes and plays a vital role in modulating the oxygen-binding affinity of hemoglobin: A. 1,3-Bisphosphoglycerate B. 2,3-Bisphosphoglycerate C. Fructose 1,6-bisphosphate D. Fructose 6-phosphate E. Glucose 6-phosphate The correct answer is B. 2,3-Bisphosphoglycerate (2,3-BPG): 2,3-Bisphosphoglycerate is a negatively charged molecule found in high concentrations within erythrocytes. 2,3-BPG

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NBME-Style Case-Based Questions on the regulation of glycolysis with explanations

Question 1: A 25-year-old man runs a marathon. After 20 miles, his muscle cells are relying heavily on glycolysis for energy production. Which of the following changes is most likely increasing the rate of glycolysis in his muscles? A. Accumulation of alanine B. Decreased availability of glucose C. Decreased oxygen levels D. Increased AMP concentration

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Amino Acid Metabolism- Set 2- Multiple Choice Questions

Q.1 – A 12-year-old boy develops convulsions. After an Electroencephalogram (EEG), a neurologist determines that the child has epilepsy. He is started on benzodiazepine, which promotes the activity of GABA. GABA is derived from Glutamate by which of the following reactions? A) Deamination B) Decarboxylation C) Dehydrogenation D) Hydroxylation E) Transamination Answer: B) Decarboxylation Explanation:

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Amino acid Metabolism- Multiple-Choice Questions- Set 1

Q.1 – Which of the following is a common compound shared by the TCA and Urea cycles? A) α-Ketoglutarate B) Succinyl-CoA C) Oxaloacetate D) Fumarate Answer: D) Fumarate Explanation: Fumarate is a common compound in both the TCA (Tricarboxylic Acid) and urea cycles. In the TCA cycle, fumarate is formed from succinate by the enzyme

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Enzymology Revision (Multiple Choice Questions With Complete Explanations)

Q.1: Glycogen phosphorylase, which mobilizes glycogen for energy, requires which of the following as a cofactor? Adenosyl Cobalamine Coenzyme A Pyridoxal phosphate Tetrahydrofolate Thiamine pyrophosphate Correct Answer: C) Pyridoxal phosphate Explanation: Glycogen phosphorylase is instrumental in the process of glycogenolysis, where it facilitates the breakdown of glycogen into glucose-1-phosphate, thereby playing a vital role in

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Biochemistry-Practice Questions (Problem-based multiple choice questions)

Biochemistry-Practice Questions (Problem-based multiple choice questions) 1)- Several complexes in the electron transport chain contain non-heme iron. The iron in these complexes is bound tightly to which of the following amino acids? a) Serine b) Tyrosine c) Cysteine d) Methionine e) Glutamine 2)- A 27 –year-old female with epilepsy has been taking Phenytoin to control

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Nonessential in normal health but essential amino acid under conditions of enhanced growth or surgical recovery

Case details An 8-year-old child requires surgical intervention and substantial recovery time in the hospital. Therefore, a nutritionist recommends a specific dietary plan. The plan includes a protein-rich diet with the special supplementation of an amino acid that is typically considered nonessential but becomes an essential amino acid under enhanced growth or surgical recovery conditions.

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