USMLE styled question bank

Elevated Acyl carnitine compounds and associated hypoglycemia- What is the defect?

Case details  A 5- year-old boy suffered gastroenteritis for two days and was brought to the emergency in the semiconscious state. Blood glucose at the time of admission was 45 mg/dl and his urine was negative for glucose and ketone bodies. Glucose was administered intravenously and his condition improved within 10 minutes. Subsequent laboratory investigations […]

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Impaired TCA cycle enzyme activity in angular stomatitis

A postoperative patient on intravenous fluids develops lesions in the mouth (angular stomatitis). Urinalysis indicates an excretion of 15 μg riboflavin/mg creatinine, which is abnormally low. Which of the following TCA cycle enzymes is most likely to be affected? Citrate synthase Isocitrate dehydrogenase Fumarase Malate dehydrogenase Succinate dehydrogenase Details- E) – Succinate dehydrogenase is the

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Gray Baby syndrome and the role of Glucuronic acid

Case details Infants have decreased ability to conjugate Glucuronic acid on to drugs such as Chloramphenicol. Administration of this antibiotic during the neonatal period can result in elevated plasma levels of the drug and a fetal shock-like syndrome referred to as Gray Baby syndrome. (Image courtesy-Gray Baby Syndrome: What You Need to Know) Glucuronic acid

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